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Signs of an allergic reaction can include itchiness, a rash, hives, chest tightness, shortness of breath and swelling of the throat, lips, mouth or tongue

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When a cell over-expresses NNMT, it does two costly things at once: it burns through methyl-donor capacity, and it diverts nicotinamide away from NAD+ regeneration into an inert metabolite (1-methylnicotinamide) that gets excreted